Found 56 matching trials
Safety and Oversight of the Individually Tailored Treatment Approach: A Novel Pilot Study NA This study is looking at outcomes in people with advanced cancers who have ...
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Peter MacCallum Cancer Centre
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TraMel-WT: A Trial of Trametinib in Patients With Advanced Pretreated BRAFV600 Wild-type Melanoma PHASE2 This phase 2 trial will investigate the efficacy and safety of trametinib a...
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Universitair Ziekenhuis Brussel
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Dabrafenib/Trametinib, BRAF or BRAF AND MEK Pre-op With BRAF and MEK Post-op, Phase IIB, Melanoma With Brain Mets,Biomarkers and Metabolites PHASE2 This is a global, multi-centre, open-label, study of GSK2118436 conducted i...
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GSK Investigational Site
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PDR001 Combination Therapy for Radioiodine-Refractory Thyroid Cancer PHASE2 The purpose of this study is to find out whether a drug called PDR001, comb...
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Active Not Recruiting
Location
Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)
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Compassionate Use Program BRAF Mutation-positive Patients in the Adjuvant Treatment of Melanoma After Surgical Resection N/A The purpose of this Treatment Plan is to allow access to trametinib and dab...
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No Longer Available
Location
Multiple Locations
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Dabrafenib and Trametinib Combination as a Neoadjuvant Strategy in BRAF-positive Anaplastic Thyroid Cancer PHASE2 The aim of the study was to evaluate the effectiveness of combination thera...
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Saint-Petersburg State University (SPSU) N.I.Pirogov Clinic of High Medical Technologies
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Compassionate Use Program to Access Trametinib and Dabrafenib for Patients With BRAF Mutation-positive Metastatic Melanoma N/A The purpose of this Cohort Treatment Plan is to allow access to trametinib ...
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No Longer Available
Location
Multiple Locations
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Efficacy and Safety of the Combination Therapy of Dabrafenib and Trametinib in Subjects With BRAF V600E- Mutated Rare Cancers PHASE2 This was a Phase II, open-label, non-randomized, multi-center study of oral...
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Novartis Investigative Site
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A Pharmacokinetics (PK) Study of the Effects Rabeprazole and Rifampin on Dabrafenib in Subjects With BRAF V600 Mutation Positive Tumors PHASE1 The study is being conducted to evaluate the effect of rifampin (a strong C...
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GSK Investigational Site
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Japan PhI/II of GSK2118436 and GSK1120212 Combination in Subjects With BRAF V600E/K Mutation Positive Advanced Solid Tumors (Phase I Part) or Cutaneous Melanoma (Phase II Part) PHASE2 This is a Japanese Phase I/II, open-label, non-controlled study to evaluate...
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GSK Investigational Site
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